TABLE OF CONTENTS
CONTENTS
Cover page
Title page i
Declaration page ii
Certification iii
Dedication iv
Acknowledgement v
Table of contents vi
Lists of Tables vii
Abstract vi
CHAPTER ONE
1.0 INTRODUCTION 1
1.1 Background of the Study 1
1.2 Statement of Problem 2
1.3 Justification of the Study 3
1.4 Aim of the Study 3
1.4.1 Objectives of the Study 3
CHAPTER TWO
2.0 LITERATURE REVIEW 4
2.1viral Hepatitis 4
2.2 Description of Hepatitis B and C virus 4
2.3 Epidemiology of Hepatitis B and C Virus 7
2.4 Transmission and Pathogenesis of Hepatitis B and C Virus 8
2.5 Clinical Presentation 10
2.6 Hepatitis B and C virus co-infection 13
2.7 Diagnosis of Hepatitis B and C Virus 14
2.8 Treatment of Hepatitis B and C virus 16
2.9 Prevention and control Hepatitis B and C virus 17
CHAPTER THREE
3.0 MATERIALS AND METHODS 19
3.1Study area 19
3.2 Study Design and study objects 19
3.3 Selection criteria ` 19
3.3.1Inclusion criteria 19
3.3.2 Exclusion criteria 19
3.5 Sample size determination 19
3.6 Data Collection 20
3.7 Ethical Consideration 20
3.8 Sample collection 21
3.9 Screening for hepatitis b and c profile among pregnant women 21
3.10 Statistical analysis 21
CHAPTER FOUR
4.0 Results 23
CHAPTER FIVE
5.0 Discussion, conclusions and recommendations 33
5.1 Discussion 33
5.2 Conclusions 34
5.3 Recommendations 35
References 36
ABSTRACTS
Hepatitis B and C infections are potentially life-threatening liver infection and a major global health problem. This study was conducted to determine the prevalence of Hepatitis B and C infections among pregnant women attending antenatal care at Federal Medical Centre Makurdi. A systematic random sampling technique was used to select pregnant women. A total of 155 pregnant women were recruited for the study. Data on sociodemographic and associated factors were collected using a structured questionnaire. Their venous blood samples collected, and hepatitis B and c profile was carried out using commercially available rapid chromatographic kits. The overall prevalence of hepatitis B and C infections among pregnant women was 7.7% and 14.19% respectively. However, there was no co-infection. Educational status was notably associated with Hepatitis B and C infections prevalence. Uneducated pregnant women had the highest prevalence of HBsAg and HCV infections (16.67% and 23.33% respectively). Age, marital status, blood transmission history, vaccination history, occupation were all factors contributing to Hepatitis B and C prevalence. This study showed that hepatitis B and C is endemic in this region. The provision of proper awareness on hepatitis B and C viruses’ transmission, vaccination, and screening of all pregnant women routinely are essential for the prevention of these viruses
